Cell Pathology

ISSN: 2750-9761

Editor-in-chief: Gloria H. Su

About this journal

The journal is closed for submissions.

Cell Pathology was a new title re-launched in 2020 in place of Endoplasmic Reticulum Stress in Diseases journal.

Cell Pathology was an open-access, peer-reviewed journal that focused on the abnormal state of cells driven by cell-intrinsic or extrinsic influences that manifest in changes of the morphology, loss of homeostasis, and/or alternations in the genetic profiles of cells. The journal welcomed anatomical, cellular, molecular, computational, mechanobiological, or organismal investigations of cell pathology and how abnormalities in cells portend to the initiation, development, and progression of human diseases.

Our journal sought high-quality original research reports, reviews, and commentaries related to all aspects of cell pathology. The editors considered basic, translational, and clinical investigations that describe novel anatomical discoveries, directly address mechanisms of pathogenesis, or provide a foundation for future cellular or molecular inquiries to aberrant physiology of cells. Examples of such foundational investigations encompass anatomical and molecular diagnostics, genomic classifications of diseases, mechanistic interrogations, and discovery research. Foundational studies that incorporate deep learning and artificial intelligence were also welcomed. High priority was given to comprehensive studies that would advance our understandings of human cell pathology and disease.

The journal is archived by De Gruyter and the independent archiving service Portico.

All authors retain copyright, unless — due to their local circumstances — their work is not copyrighted. The copyrights are governed by the Creative-Commons license.

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Volume 7 Issue 1

January 2021

Open Access May 12, 2021

Rhinoscleroma – A unique masquerader. A retrospective case series

Deepak Nayak M., Laxmi Shenoy

Page range: 1-6

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Abstract

Objectives: Rhinoscleroma is a rare infectious disease of the upper respiratory tract caused by Klebsiella rhinoscleromatis . Apart from mandating an appropriate antibiotic therapy, it poses a unique challenge to the pathologists since it can clinically simulate a malignancy. The main objective was to study the cases of rhinoscleroma of the respiratory tract in a period of 3 years with an emphasis on the clinico-pathologic features. Methods: We report a retrospective analysis of 7 cases, histopathologically diagnosed at our centre as rhino-scleroma. The topography ranged from nasal mucosa (3), pharynx (2) and larynx (2). Results: Histopathological examination in all cases showed diffuse aggregates of foamy macrophages (Mikulicz cells) containing intracytoplasmic basophilic organisms; admixed with plasma cells in a fibrotic stroma. The overlying epithelium appeared atrophic to focally hyperplastic. The age ranged from 36–67 years, involving both genders. The significant clinical history included a nasal block without anosmia, atrophic rhinitis with septal perforation to subglottic stenosis, requiring immediate surgical intervention. In 4 of the 7 cases, the working clinical diagnosis was stipulated as a malignancy. Conclusions: Rhinoscleroma can affect different regions in the upper aero digestive tract. A lack of awareness and a delay in the diagnosis of this disease can lead to complications including upper airway obstruction, physical deformity, and rarely, sepsis. In addition, it must be remembered that the treatment of rhinoscleroma is challenging and requires a prolonged course of antibiotics to achieve a definite cure and avoid relapses.

Open Access April 18, 2022

Effects of zoledronic acid on bone structure and organization of nanocomposites in rats with obesity and limited mobility

N.M. Kostyshyn, I.I. Shtablavyi

Page range: 7-14

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Abstract

Background: Some investigations show that obesity is associated with increase in bone mass due to excessive mechanical exertion. However, these data are contradictory as loss of mineral density of bone tissue and, respectively, the risk of fractures in this population group is higher. The aim of the research was to investigate impact of drug therapy with zoledronic acid on nanostructure of bones in rats with limited mobility and high-calorie diet. Methods: Rats (n = 56) were distributed into three groups: control (n = 18) – standard vivarium conditions, І experimental group (n = 18) – rats, which were on a high-calorie diet with limited mobility (HCD+LM), ІІ experimental group (n = 18) – HCD+LM+zoledronic acid. Zoledronic acid was injected at the dose 0.025 mg/kg intramuscularly every four weeks for six months. X-ray structure analysis, scanning electron microscopy and atomic absorption spectrometry were used for investigation of ultrastructure and quantitative assessment of mineral component loss in the femoral neck. Results: Obesity and limited mobility reduced the level of the mineral component in the femoral neck (−31.5%) compared with control. It is significant that zoledronic acid did not permit decrease in mineral component of the bone throughout the entire experiment compared with group I (+41.8%), and all parameters were higher than in control group (+15%). Conclusions: Obesity and limited mobility negatively affect mineral bone mass. Zoledronic acid induces increase in the mineral component as a result of remodeling inhibition under conditions of obesity and limited mobility modeling.

Open Access May 22, 2022

Intramuscular hydatid cyst of thigh masquerading as a soft tissue tumour diagnosed by fine needle aspiration cytology

K Amita, T Rajini, M Sanjay, MG Abhishek, K Prashantha

Page range: 15-19

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Abstract

Introduction. Hydatid cyst, caused by Echinococcus granulosa , occurs rarely in the musculoskeletal region. Most of the time, clinically and radiologically it is diagnosed as a soft tissue tumor, benign or malignant. There are a few case reports of hydatid cyst presenting as an intramuscular thigh mass, which has been diagnosed at fine needle aspiration cytology (FNAC). Accurate pre-operative diagnosis is essential in view of specific therapeutic options for this disease. Here we report a case of hydatid cyst occurring in an unusual location (thigh) and masquerading as a soft tissue tumour, diagnosed at FNAC. Case Report. 56-year-old male patient presented with gradually increasing swelling of the left thigh since 3 years. On examination, there was a firm non-tender 25 × 20 cm swelling on the posterior aspect of left thigh extending from the gluteal region to five cm above the knee joint. An ultrasound diagnosis of a soft tissue tumor was made. At FNAC, fluid was aspirated and smears showed granulomas along with multiple hyaline acellular membrane-like fragments, few showing vague laminations. A diagnosis of hydatid cyst was made at FNAC which was corroborated at histopathology. Conclusion. Intramuscular hydatid cyst of the thigh is a very rare manifestation. The possibility of hydatid cyst should be considered while aspirating any soft tissue mass lesion, especially when fluid is obtained and microscopy shows acellular hyaline membrane-like material, even when fewer laminations are noted.

Volume 7 (2021)

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Editorial

Editorial Contact
Agnieszka Bednarczyk-Drąg, De Gruyter
agnieszka.bednarczyk-drag@degruyter.com

Publisher
DE GRUYTER Poland
Bogumiła Zuga 32A Str.
01-811 Warsaw, Poland
T: +48 22 701 50 15

(Deutsch)

Type: Journal
Language: English
Publisher: De Gruyter Open Access
First published: August 7, 2012
Last published: January 1, 2021
Publication Frequency: 1 Issue per Year
Audience: researchers, physicians, students