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Baseline JAK–STAT signaling maintains immune cell homeostasis
Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK–STAT signaling supports the characteristic transcriptional and epigenetic state of homeostatic T cells and macrophages in mice. JAK–STAT signaling under homeostatic conditions was driven by signals from healthy tissue and did not require external immune stimuli.
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IL-1-mediated inflammation induced by different RNA vaccines is context-specific
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JAK-STAT signaling maintains homeostasis in T cells and macrophages
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Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation
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Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency