Records of Natural Products

A new bisabolane sesquiterpenoid, named calkbisabenacid (1), was isolated from the leaves of Callicarpa kwangtungensis, along with four known compounds: 5-O-coumaroylquinic acid (2), kaempferol (3), and soyasapogenol B (4). The structure of compound 1 was determined by 1H NMR, 13C NMR, COSY, HSQC, and HMBC spectra, in combination with the HRESIMS data. The absolute configuration of C-1 in compound 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra of the two possible stereoisomers. The known compounds were identified by comparing their NMR data with those reported in the literature. Compound 4 was isolated from this species for the first time. None of these compounds demonstrated any inhibitory effects against Staphylococcus aureus ATCC 25923.

The aim of this study is to investigate the chemical composition of ethanol, acetone extracts and essential oil of the roots and aerial parts of Sanguisorba minor subsp. muricata. Flavonoids and phenolic acids were identified as the main components in the studied extracts herein. Rutin and quercetin-3-sophoroside were found to be dominant flavonoids in both extracts. Although it was observed that the determined chemical compositions of the essential oil obtained from the aerial parts and roots of the plant species were quite different from the data obtained by Headspace measurement, as expected, the essential oils obtained from the species were found to be rich in mainly monoterpene hydrocarbons and oxygenated monoterpenes. While salicylaldehyde, carvacrol and linalool were determined as the main components in the essential oil obtained from the aerial parts of the species, the main components in the essential oil obtained from the roots were observed as borneol, myrtenol and α-campholenol.

The genus Cercis, belonging to the Fabaceae family, is widely distributed in China and traditionally employed in Chinese medicine to treat various disorders, like irregular menstruation, pain, cough and carbuncle swelling. Despite the availability of numerous scientific studies on this genus, reviews that comprehensively cover its phytochemistry and pharmacology remain limited. This review aims to systematically consolidate the scientific literature on the phytochemistry and pharmacology of eight Cercis species, retrieved from databases like PubMed, Web of Science, SciFinder, Google Scholar, and the China National Knowledge Infrastructure platform. Based on a thorough analysis of the literature, more than 100 compounds have been identified from Cercis species, including flavonoids, phenols, terpenoids, lignins, dibenz[b,f]oxepins and others. Extracts and chemical constituents derived from Cercis species exhibite significant antioxidant, analgesic, anti-inflammatory, antitumor, antibacterial activities. These findings contribute to a deeper understanding of the medicinal potential of Cercis species and their potential applications in healthcare.

Nine known compounds were isolated from the P. serrata roots and showed promising inhibitory activity against α-glucosidase. The molecular docking study of them was exhibited the 4-hydroxyl group in the aromatic ring of benzoic acid derivatives improves the bioactivity. Network pharmacology was performed to investigate the molecular mechanisms of isolated compounds and suggested that the insulin resistance pathway would be a primary mechanism of action. This is the first time the α-glucosidase inhibitors of P. serrata roots were reported.